Preconception Genetic Testing
Plan with Confidence: Unlocking the Path to a Healthy Future for Your Family
At FIV Valencia, we offer both the Genetic Compatibility Test and Preimplantation Genetic Diagnosis as two Preconception Genetic Tests recommended for cases that may require genetic analysis before Assisted Reproduction treatment.
GCT Test and Testing for Genetic Disorders
The Genetic Compatibility Test (GCT) is a simple blood test that helps determine whether prospective parents carry specific genetic mutations that could lead to serious conditions in their children. By identifying potential genetic risks early, we can support both natural and assisted pregnancies.
While carriers of many genetic disorders may not show symptoms, if both parents carry a mutation in the same gene, then there is a risk it could be passed on to their child. The GCT test helps identify these risks by analysing approximately 368 recessive and sex-linked genetic conditions, including:
- Cystic fibrosis
- Spinal muscular atrophy
- Metabolic disorders (e.g., phenylketonuria)
- Visual and hearing disorders
- Musculoskeletal disorders
- Skin conditions
If both partners are found to carry the same mutation, we offer genetic counselling at FIV Valencia to discuss the available options, including the possibility of In Vitro Fertilisation (IVF) with Preimplantation Genetic Diagnosis (PGD) to help reduce the risk of passing on the condition.
The GCT test also identifies mutations that may impact fertility treatments, such as those affecting blood clotting or response to hormone treatments. This test is widely used in gamete donation programs, but it is also available to any couple wishing to understand their genetic health.
Who is the GCT Test Suitable For?
The GCT test is suitable for couples wishing to understand their genetic compatibility before starting a family. This test can confirm or rule out key mutations, but it does not eliminate the possibility of all mutations in the tested genes. Therefore, the results indicate a “residual risk of transmission,” helping assess the likelihood of passing on genetic conditions based on both partners’ genetic profiles.
This test is especially useful for:
By performing this blood test on both partners, we can identify if there is a shared mutation responsible for certain genetic diseases. If such a mutation is detected, FIV Valencia offers genetic counselling and the option of In Vitro Fertilisation with Preimplantation Genetic Testing (PGT) to assess embryos for potential risks.
- Couples with a family history of genetic disorders
- Those planning to conceive naturally or through Assisted Reproduction
- Anyone looking to understand their genetic risks
Preconception Examinations
Preconception Genetic Testing generally includes a range of evaluations to provide a thorough understanding of both partners’ genetic health, helping to design an optimal treatment plan for conception and a healthy pregnancy. These examinations generally include:
Based on the results of these preconception examinations, FIV Valencia specialists will propose the optimal treatment plan, potentially including IVF with Preimplantation Genetic Testing (PGT) of embryos. Our goal is to help you achieve a successful pregnancy and the birth of a healthy baby, tailoring your treatment based on your genetic testing results—100% with your needs in mind.
- Clinical Genetic Testing: Reviewing the personal and family history of both partners within the context of genetic counselling. This helps identify any hereditary conditions that may pose a risk to future children.
- Chromosomal Examination: A microscopic analysis of chromosomes in both partners to identify abnormalities. Chromosomes are structures in the cell nucleus containing blocks of genes.
- Blood Clotting Predisposition in Women: Identifying genetic predispositions that might affect responses to Assisted Reproduction treatments and pregnancy, such as hormonal response through follicle stimulating hormone receptor (FSHR) gene analysis.
- Hidden Carrier Testing for Common Hereditary Diseases: This includes the GCT test to identify conditions like cystic fibrosis (CF) and spinal muscular atrophy (SMA), as well as other rare diseases that may impact a child’s senses (e.g., hearing impairment) or metabolism (e.g., congenital metabolic disorders).
- Y-Chromosome Microdeletion Testing: Recommended for men with significantly impaired sperm quality. This test identifies deletions on the Ychromosome (AZF - azoospermia factor), which can impact fertility.
Costs of Preconception Genetic Testing
Understanding the costs of Preconception Genetic Testing is essential when planning for your family. Expenses can vary depending on the specific tests required and the level of detail involved. Some insurance plans may cover all or a part of these costs, especially if there is a known family history of genetic
disorders. For detailed pricing information, please refer to our price list.
Preconception Genetic Testing
FAQs
Why should I consider Preconception Genetic Testing before getting pregnant?
These tests may be especially relevant if you have a family history of genetic disorders, suffer from infertility or recurrent miscarriages, or simply want to understand your genetic compatibility with your partner. They offer information on potential risks, helping you plan for a healthy pregnancy.
What does Preconception Genetic Testing involve?
Preconception Genetic Testing typically includes a blood test to analyse your genes, as well as a review of your personal and family medical history. These tests can identify specific genetic mutations linked to hundreds of recessive and sex-linked diseases, helping you assess the risk of passing these conditions onto your children.
Can Preconception Genetic Testing detect all genetic disorders?
While Preconception Genetic Testing can identify many common genetic mutations, it cannot detect every possible genetic disorder. It provides a comprehensive overview of key risks, but there remains a “residual risk” for conditions not covered by the test.
How is the GCT test different from other genetic tests?
The Genetic Compatibility Test (GCT) specifically searches for mutations in genes responsible for autosomal recessive and sex-linked diseases. It screens for 368 conditions to determine if both partners carry the same mutation, which could pose a risk to their children.
Who should consider the GCT test?
The GCT test is recommended for anyone planning to start or expand their family, particularly if there is a known family history of genetic disorders. It can be useful for couples conceiving naturally, through Assisted Reproduction, or using gamete donation.
How long does it take to get the results of Preconception Genetic Testing?
The timeframe varies depending on the specific tests performed, but results are typically available within a few weeks. Your geneticist will discuss the findings with you and provide guidance on the next steps if any risks are identified.
What happens if a genetic risk is identified?
If the test identifies a genetic risk, we offer genetic counselling to discuss your options. This may include Preimplantation Genetic Diagnosis (PGD) if you're considering Assisted Reproduction or other steps to manage and reduce the risk of passing on the genetic condition.
How do I prepare for Preconception Genetic Testing?
Before your appointment, it’s helpful to gather information about your family’s medical history, including any known genetic conditions or patterns of illness. This information provides valuable context for testing and helps guide the discussion during genetic counselling.