Embryo Implantation Support 

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EmbryoGlue

EmbryoGlue helps embryos adhere to the uterus following embryo transfer during an In Vitro Fertilisation (IVF) treatment. 

EmbryoGlue is a special culture medium used during embryo transfer in an IVF treatment to increase the chances of the embryo implanting successfully in the uterus. This solution is enriched with nutrients and contains a high concentration of a natural substance called hyaluronan, which plays a key role in helping the embryo adhere to the uterine lining. 

How Does EmbryoGlue Help with Embryo Implantation? 

  • Hyaluronan's Role: Hyaluronan is a substance naturally found in the body and is crucial in the process of embryo implantation. In EmbryoGlue, it interacts with the embryo and the uterus, helping the embryo attach to the uterine lining more effectively. 
  • Mimicking the Natural Environment: EmbryoGlue creates an environment similar to what the embryo would naturally encounter in the uterus. This supportive setting facilitates embryo implantation and the beginning of its development. 

Why Consider Using EmbryoGlue? 

Improved Pregnancy Rates
Studies have shown that using EmbryoGlue can increase the chances of a successful pregnancy. Clinical pregnancy rates have increased from 41% to 49% compared to using standard culture mediums in an IVF treatment. 
 
Extra Implantation Support
If you have had difficulties with implantation in the past or want to give your embryo the best possible chance, EmbryoGlue provides additional support during this critical phase. 

How is EmbryoGlue Used? 

Supporting Implantation

Once the embryo is in your uterus, EmbryoGlue continues to support the implantation process, giving it a better chance to attach and grow. 

Preparation for Transfer

After your embryo has developed in the laboratory, it is placed in EmbryoGlue just before being transferred to your uterus. 

Transfer Process

During embryo transfer, the embryo surrounded by EmbryoGlue is gently placed in your uterus. The hyaluronan in the solution helps the embryo adhere to the uterine lining. 

Benefits of Using EmbryoGlue 

EmbryoGlue offers a simple yet effective way to support your embryo during one of the most important stages of IVF implantation. By providing an optimal environment for implantation, EmbryoGlue helps increase the chances of a successful pregnancy and enhances the success rate of In Vitro Fertilisation. 

  • Natural Assistance: EmbryoGlue helps the embryo interact naturally with the uterine lining and assists during the delicate process of implantation. 
  • Proven Success: It increases the chances of implantation and, therefore, of pregnancy. It enhances the outcomes of your Assisted Reproduction treatment. 
  • Safe and Non-Invasive: This solution is safe, can be used in any IVF cycle, and facilitates the embryo's adhesion to the uterus. 
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Assisted Hatching

In an IVF treatment, assisted hatching is a highly precise technique used in the laboratory to help embryos implant more easily into the uterus. 

  

Every embryo has a protective outer layer called the zona pellucida. For successful implantation, the embryo must "hatch" out of this layer and attach to the uterine lining. Sometimes, this outer layer can be too thick or resistant, making it difficult for the embryo to break through on its own. Assisted hatching helps by creating a small opening in this layer, giving the embryo extra help to hatch and implant. 

How Does Assisted Hatching Work? 

Assessment

Before the procedure, the embryologist carefully examines the embryos to determine if assisted hatching is necessary. It is recommended when the zona pellucida appears thicker than normal or when pre-implantation genetic testing (PGT) is planned. 

Creating the Opening

Using a very precise laser, the embryologist creates a small opening or thins the zona pellucida. This step is performed through a microscope to ensure precision and to avoid damaging the embryo. 

Supporting Implantation

By creating this small opening, assisted hatching makes it easier for the embryo to break out of its outer shell and adhere to the uterus, increasing its chances of implantation and a successful pregnancy. 

When is Assisted Hatching Recommended? 

In an IVF treatment, assisted hatching may be indicated in the following situations: 

  • Thick Zona Pellucida: If the embryo's outer shell is unusually thick or hard, assisted hatching can help the embryo hatch more easily. 
  • Previous IVF Attempts: If previous IVF cycles have resulted in good-quality embryos but without successful implantation, assisted hatching could be used to improve the chances of success in a new treatment. 
  • Advanced Maternal Age: For women over the age of 35, the zona pellucida can become more rigid, making it harder for the embryo to hatch naturally. 
  • Planned Genetic Testing or Pre-Implantation Genetic Testing (PGT): When pre-implantation genetic testing is planned, assisted hatching can facilitate the process. 

Benefits of Assisted Hatching in IVF Treatment 

Assisted hatching is a small but significant step that can make a big difference in the success of your IVF cycle. By giving the embryo extra help to break free from its protective layer, this technique increases the chances of implantation and, therefore, the chances of pregnancy. 

Easier Embryo Implantation
By helping the embryo break out of its outer shell, assisted hatching can improve the chances of the embryo successfully implanting into the uterine lining. 
Enhanced Success Rates
This technique can increase overall IVF success rates, especially for those who have had difficulties with embryo implantation in previous cycles. 
Personalized Care:
Assisted hatching is selectively used based on the specific needs of each embryo, responding to a personalized approach to improve implantation chances. 

Costs of Specialised Laboratory Techniques 

While special laboratory techniques can increase the total cost of IVF treatment, it is important to consider the potential benefits they offer. Costs vary according to the specific techniques used and the complexity of each case. At FIV Valencia, we provide a detailed breakdown of these costs from the start of treatment to help our patients make informed decisions about incorporating these advanced methods into

their treatment plan.

For more information, please refer to our Price List.

Price List Book a consultation

Embryo Implantation Support

FAQs

What is embryo implantation support?

Embryo implantation support in an IVF treatment includes techniques and methods designed to improve the chances of an embryo successfully adhering to the uterine lining. This includes specialised procedures like EmbryoGlue and assisted hatching. 

What is EmbryoGlue and how does it work?

EmbryoGlue is a special transfer medium enriched with nutrients and a high concentration of hyaluronan. It helps enhance the embryo's ability to adhere to the uterine lining by mimicking natural conditions, increasing the chances of successful implantation. 

Who can benefit from using EmbryoGlue?

EmbryoGlue can be beneficial for anyone undergoing IVF treatment, especially those who have experienced previous implantation failures or who want to maximize their chances of success during embryo transfer. 

How does EmbryoGlue improve implantation rates?

EmbryoGlue has been shown to significantly increase clinical pregnancy rates, from 41% to 49%. The high concentration of hyaluronan in EmbryoGlue supports the adhesion of the embryo to the uterus, creating an optimal environment for implantation. 

Is it safe to use EmbryoGlue during IVF?

Yes, EmbryoGlue is a safe and effective medium used at many IVF clinics worldwide. It is designed to support the embryo during transfer and to improve implantation without causing harm. 

What is assisted hatching, and when is it recommended?

Assisted hatching is a technique in which a small opening is made in the embryo's outer shell (zona pellucida) to help it hatch and implant in the uterus. It is recommended in cases with a thick zona pellucida, previous IVF failures, advanced maternal age, or when pre-implantation genetic testing (PGT) is planned. 

How is assisted hatching performed?

Assisted hatching is performed by an embryologist using a precise laser to create a small opening in, or to thin, the zona pellucida. It is carried out under a microscope to ensure safety and precision, helping the embryo break through and implant more easily. 

Does assisted hatching increase the chances of pregnancy?

Assisted hatching can improve the chances of successful implantation, especially in cases where the embryo may have difficulty hatching on its own. It offers additional support to enhance the overall success of the IVF cycle. 

Are there any risks associated with assisted hatching?

Assisted hatching is generally considered safe, although, as with any procedure, there are minimal risks. The technique is performed with great care to avoid harming the embryo. In our center, your doctor will discuss the possibility of using this technique in your treatment. 

Can I use both EmbryoGlue and assisted hatching in my IVF cycle?

Yes, EmbryoGlue and assisted hatching can be used together in an IVF cycle if recommended by your fertility specialist. Both offer different benefits that complement each other to improve the chances of implantation. 

How do I know if I need embryo implantation support?

Your doctor will evaluate your specific situation, including previous IVF results and any factors that may affect implantation, to determine if implantation support techniques like EmbryoGlue or assisted hatching are right for you. At FIV Valencia, we prioritize providing our patients with all the necessary information and support throughout their treatment. 

Does embryo implantation support guarantee a successful pregnancy?

While techniques like EmbryoGlue and assisted hatching can significantly improve the chances of implantation, they do not guarantee a successful pregnancy. Many factors influence the success of an IVF cycle, but these methods provide additional support during this crucial stage.